A study of the relation of marijuana use to psychosocial disorders

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A study of the relation of marijuana use to psychosocial disorders

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Raby reports no affiliation with or financial interest in any organization that may pose a conflict of interest. This article includes discussion of the following unapproved medications for co-occurring marijuana abuse or dependence and psychotic disorders: Please direct all correspondence to: Abstract Marijuana abuse can lead to transient psychosis, but can it cause or worsen psychotic disorders like schizophrenia?

This article reviews the evidence from key research reports, leading to the conclusion that marijuana use, especially in early adolescence, can lead to psychotic disorders in adulthood, such as schizophrenia.

There is a want of treatment approaches for marijuana use in individuals with schizophrenia, or for emerging psychosis in patients dependent on marijuana.

Second-generation antipsychotics, especially clozapine, appear to be the best approach to treatment for psychosis co-occurring with—and often secondary to—marijuana abuse. More research is needed to develop appropriate and effective treatments for marijuana dependence, both alone as well as in conjunction with psychosis and psychotic disorders.

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Introduction Is marijuana dangerous? With an estimated million people worldwide smoking or eating marijuana leaves annually,1 the question is pertinent. Marijuana is perceived as an innocuous drug in many circles due to its association with cultural and religious rituals, and with the fact that unlike alcohol, cocaine, or heroin, it rarely brings individuals to the brink of destitution.

However, this perception is changing. InTanda and colleagues2 reported that marijuana, like most drugs of abuse, increases dopamine release in the nucleus accumbens.

A study of the relation of marijuana use to psychosocial disorders

Moreover, the increasing potency of available marijuana has led to the recognition of a withdrawal syndrome, characterized by irritability, restlessness, insomnia, anorexia, and aggressivity, which may last up to several weeks after stopping marijuana.

This last point will be the focus of this article, which will review of the evidence, discuss clinical symptoms that may indicate an enhanced risk of psychosis stemming from marijuana, and present available treatment options.

Review of the Evidence Linking Marijuana to Psychosis Marijuana use appears to be beginning at an increasingly early age. Strictly with respect to psychosis, results from the US National Epidemiological Catchment Area Study7 highlight that daily marijuana smokers were 2.

Before inquiring about psychotic disorders, this article evaluates how prone marijuana users are to experience some form of psychosis. As early asmarijuana use was stated to possibly cause acute psychosis.


Mild intoxication causes drowsiness, euphoria, and heightened sensory perception, while severe intoxication leads to motor incoordination, lethargy, and postural hypotension. Cross-sectional studies have attempted to look at the types of symptoms that might be elicited by marijuana: While methodologic differences abound in these studies, these studies imply that marijuana users are more prone to transient positive symptoms of psychosis; one study15 found an association with negative symptoms as well.

Using a method called Experience Sampling Method, which is a structured daily diary method to investigate subjective experience during daily life in which subjects a prompted every three hours to complete the diary, Verdoux and colleagues18 found that in a given 3-hour period the likelihood of reporting unusual perceptions was increased if marijuana was used in the same 3-hour period, and not if used in the previous three hour period.

This finding is consistent with the estimated duration of the pharmacologic effects of marijuana. National surveys support this association, such as the data from the US National Epidemiological Catchment Area study7 presented earlier.

Two other national surveys also concur. After adjusting for other disorders and sociodemographic factors, individuals with cannabis dependence were found to be nearly three times as likely to be diagnosed with schizophrenia as those not diagnosed with cannabis dependence.

However, they cannot answer the question: The issue of causality is a difficult one to answer when it comes to conditions such as psychosis which can have multiple etiologies. To establish causality, three factors must be established: Two landmark prospective studies will be reviewed: It gathered information on self-reported psychotic experiences at 11 years of age, before the onset of marijuana use, and on self-reported use of marijuana at 15 and 18 years of age.

All individuals were assessed to yield Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition28 diagnoses if present at 26 years of age, allowing the investigators to note the presence of psychotic symptoms along a continuum or the presence of a formally diagnosed psychotic disorder.

Psychotic symptoms stemming from alcohol or other drugs were ruled out. Cannabis use by 15 and 18 years of age, respectively, led to higher rates of psychosis at age 26 compared to non-users, even after controlling for psychotic experiences preceding marijuana use.

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Age of first marijuana use was a significant factor: The risk for adult schizophreniform disorder remained elevated after controlling for psychotic experiences at 11 years of age, with an odds ratio of 3.

Marijuana use by 15 years of age did not predict depression at 26 years of age, and other drug use did not pose a risk for schizophreniform disorder above the one posed by marijuana.Dear Twitpic Community - thank you for all the wonderful photos you have taken over the years.

We have now placed Twitpic in an archived state. Recidivism (/ r ɪ ˈ s ɪ d ɪ v ɪ z əm /; from recidive and ism, from Latin recidīvus "recurring", from re-"back" and cadō "I fall") is the act of a person repeating an undesirable behavior after they have either experienced negative consequences of that behavior, or have been trained to extinguish that behavior.

It is also used to refer to the percentage of former prisoners who are. A study published in the journal Psychological Medicine examined the relationship between marijuana use and the risk for schizophrenia.

Researchers found some evidence linking cannabis use with an increased risk for schizophrenia.

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Study: No Link Between Cannabis And Suicidal Behavior for Most Psychiatric Patients Incarceration in the United States Recidivism rates in the U. Crime continues inside many prison walls.

This study also concluded that people at risk for schizophrenia are more likely to try cannabis. A longitudinal study of cannabis use and mental health from adolescence to early adulthood () McGee R, Williams S, Poulton R, Moffitt T.

Addiction; ; Mental health of teenagers who use cannabis () Rey JM et al. British Journal of Psychiatry, , A new Canadian study finds no notable link between cannabis use and suicidal behavior in most people with psychiatric disorders.

The findings, published in the journal Biology of Sex Differences, contrast with previous data suggesting that the drug is associated with an increased risk of suicidal behavior in the general population.

Request PDF on ResearchGate | Psychosocial Factors Related to Cannabis Use Disorders | The objective of this study was to explore the association between psychosocial risk and protective factors and cannabis use disorders (CUDs) in a cohort of African American and Puerto Rican young adults.

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