Species Serratia marcescens on an XLD agar plate. Obtained from the CDC Public Health Image Library Description and Significance Serratia marcescens is a motile,short rod-shaped, Gram-negative, facultative anaerobe bacterium, classified as an opportunistic pathogen. It was discovered in by Bartolomeo Bizio in Padua, Italy. Bizio named the genus Serratia in honor of and Italian physicist named Serratia, and chose marcescens for the species name after the Latin word for decay .
It metabolizes by either respiratory or fermentative processes classifying it as a chemoorganotroph 4. Ubiquitous in nature, S. In particular, food sources that provide a nutrient rich environment include starchy variants The bacterium propels itself in these different environments using peritrichous flagellum 4.
Identifiable in ecological niches by their red pigment, prodigiosin 2-methylpentymethoxyprodigiosinS. Since this pigment is easily recognized in certain strains due to its red coloring, it has been extensively used as a biological marker However, not all strains contain red pigment and most clinical isolates of S.
Also, prodigiosin has antibacterial, antifungal, antiprotozoan, and immunosuppressant activity. Environmental signals such as temperature, phosphate limitation, and medium components regulate prodigiosin production. Prodigiosin is not the only secreted product, many more include protease, nucleases, lipase, chitinase, the biosurfactant serrawettin, and hemolysin A broad range of hospital-acquired infections caused by S.
Reports have shown rare cases of S. These cases are linked to patients with immune deficiencies or chronic debilitating diseases.
Many problems arise in treating nosocomial infections because of resistance to a variety of antibiotics, such as cephalosporins, aztreonam, imipenem, cefotaxime, and ceftazidime 16, Therefore, novel treatment techniques are in need to eliminate infections without overuse of the antibiotic Studies have shown that S.
Not only do these organisms adhere to biotic substrates but they are also found on abiotic substrates such as contact lenses.
These organisms may possess pili that foster their adherence as well as an O-antigen that has a strong influence on the adhesion to abiotic and biotic surfaces In particular, such interactions are mediated by large surface pili called type 1 fimbriae Biofilms are formed when S.
When these microbes aggregate together they can communicate with one another via quorum sensing. Organisms can benefit from biofilms because they are proposed to provide protection against external stress. However, when cells reach high densities within a biofilm this may result in stressful environments classified by limited nutrients and oxygen, nonoptimal pH, and accumulation of metabolic by-products.
Therefore, it is important that S. Biofilms play an important role in disease of humans and plants, and Koh et al. Moreover, different stages of biofilm development showed specialized traits displaying different phenotypic variants Figure 1.
Studies will better understand microbial evolution processes by functional diversification within the biofilm Ultimately, this information could be useful to better understand the diversification of S.
Antibiotic Susceptibility The external face of the outer membrane of S. The outer membrane that surrounds this gram negative bacterium cell protects it from toxic agents by slowing their penetration and hindering their access to the target site.
LPS is composed of parts that include the O-antigen, lipid A, and the core In several Enterobacteriaceae species, efflux by RND-type transporters is known to confer resistance to an antibiotic, tigecycline.
In gram negative bacteria, RND-type efflux systems usually have a cytoplasmic membrane pump, a periplasmic component, and an outer membrane channel.
Serratia marcescens. Serratia marcescens is the most common species of Serratia found in hospitals, and the only pathogenic species of Serratia, except for rare reports of diseases resulting from infection with Serratia plymuthica,Serratia liquefaciens, Serratia rubidaea, and Serratia odorifera. Mar 06, · One year ago, I had one of the worst experiences a hospital epidemiologist can have: a Serratia marcescens outbreak in a neonatal department with a total of 21 colonized or infected newborns. This outbreak caused headlines in all national TV channels and newspapers for at least one week in Germany. Nov 22, · INTRODUCTION. Serratia marcescens is an opportunistic, gram negative, nosocomial pathogen which belongs to family, Enterobacteriaceae. It was discovered by Bizio, an Italian pharmacist, in , when he identified it as a cause of the bloody discolouration on cornmeal mush.
However, the outer membrane channels in S. In this present study, up-regulation of endogenous SdeXY-HasF mediated efflux is associated with tigecycline resistance in S. Kumar and Worobee studied fluoroquinolone resistance of S. They examined four fluoroquinolones ofloxacin, ciprofloxacin, norfloxacin, and nalidixic acid to determine the drug specificity of efflux.
Western immunoblot experiments demonstrated the presence of at least two AcrA-like proteins in S. Infection, Diagnosis, Prevention, and Treatment S. In this case, solutions used for medical purposes, catheterizations, and needle punctures can be contaminated and infect patients Patients may also be infected with S.MICROBIOLOGY.
Once considered a harmless saprophyte, Serratia marcescens is now recognized as an important opportunistic pathogen combining a propensity for healthcare-associated infection and antimicrobial resistance. Serratia marcescens is a member of the genus Serratia, which is a part of the family benjaminpohle.comtly 14 .
Serratia marcescens is a rare opportunistic bacterium that is categorized in the enterobateriaceae family commonly found in the environment. The bacteria can produce prodigiosin, a pigment color that ranges from lights pink to dark red.
The color can identify the age of the bacterial colony which thrives in the soil, water, and the digestive tract of many mammals, including humans.
Serratia marcescens (/ s ə ˈ r eɪ ʃ i ə m ɑːr ˈ s ɛ s ɪ n z /) is a species of rod-shaped gram-negative bacteria in the family Enterobacteriaceae.A human pathogen, S. marcescens is involved in hospital-acquired infections (HAIs), particularly catheter-associated bacteremia, urinary tract infections and wound infections, and is responsible for % .
Mar 01, · Serratia species are opportunistic gram-negative bacteria classified in the tribe Klebsielleae and the large family Enterobacteriaceae. Serratia are widespread in the environment, but are not a common component of the human fecal flora.
By [Brittany Currey] Serratia marcescens, a rod-shaped gram-negative bacterium ( µm in diameter and µm in length), is a member of the Enterobacteriaceae family (4, 11).It is a facultative anaerobe that can grow in the presence and absence of oxygen at .
Serratia Marcescens is a human pathogenic species of Serratia. It is sometimes linked to disease in humans. The disease is commonly known as either Serratia plymuthica, Serratia liquefaciens, Serratia rubidaea, Serratia odorifera, or Serratia fonticola.